Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

Frozen shoulder is a common debilitating disorder characterized by shoulder pain and
progressive loss of shoulder movement. Frozen shoulder is frequently associated with other …

Tendinopathy is a multifactorial spectrum of tendon disorders that affects different
anatomical sites and is characterized by activity-related tendon pain. These disorders are …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as
mediators of disease pathology via coordinated regulation of molecular effector pathways …

Background The cellular mechanisms of tendinopathy remain unclear particularly with
respect to the role of inflammation in early disease. The authors previously identified …

Psoriasis is a common chronic autoimmune condition of the skin characterized by
hyperplasia of epidermal keratinocytes associated with pro‐inflammatory cytokines. IL‐33 is …

The role of inflammatory cells and their products in tendinopathy is not completely
understood. Pro-inflammatory cytokines are upregulated after oxidative and other forms of …

MicroRNA (miRNA) has the potential for cross-regulation and functional integration of
discrete biological processes during complex physiological events. Utilizing the common …

Objectives To seek evidence for the role of hypoxia in early human tendinopathy, and
thereafter to explore mechanisms whereby tissue hypoxia may regulate apoptosis …