Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a
common end point of various types of renal disease. To date, the biological meaning of …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …

There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however,
cancer therapies targeting TSCs are limited. A drawback is that TSC markers are often …

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia.
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …

SGLT2 inhibitors offer strong renoprotection in subjects with diabetic kidney disease (DKD).
But the mechanism for such protection is not clear. Here, we report that in damaged proximal …

Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and
states that are also implicated in tissue dysfunction and pathogenesis. Here we leveraged …

AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain
unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal …

Exposure of articular cartilage to excessive mechanical loading is deeply involved in the
pathogenesis of osteoarthritis. Here, we identify gremlin-1 as a mechanical loading …

Excessive fat intake contributes to the progression of metabolic diseases via cellular injury
and inflammation, a process termed lipotoxicity. Here, we investigated the role of lysosomal …