High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

W Hoepel, HJ Chen, CE Geyer… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

Antibody development after COVID-19 vaccination in patients with autoimmune diseases in the Netherlands: a substudy of data from two prospective cohort studies

L Boekel, M Steenhuis, F Hooijberg… - The Lancet …, 2021 - thelancet.com
Background Data are scarce on immunogenicity of COVID-19 vaccines in patients with
autoimmune diseases, who are often treated with immunosuppressive drugs. We aimed to …

Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

L Wieske, KPJ van Dam, M Steenhuis… - The Lancet …, 2022 - thelancet.com
Background Disease-specific studies have reported impaired humoral responses after
SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders treated …

Breakthrough SARS-CoV-2 infections with the delta (B. 1.617. 2) variant in vaccinated patients with immune-mediated inflammatory diseases using …

L Boekel, EW Stalman, L Wieske… - The Lancet …, 2022 - thelancet.com
Background Concerns have been raised regarding the risks of SARS-CoV-2 breakthrough
infections in vaccinated patients with immune-mediated inflammatory diseases treated with …

A ban on BAM: An update on inhibitors of the β-barrel assembly machinery

M Steenhuis, P van Ulsen, NI Martin… - FEMS microbiology …, 2021 - academic.oup.com
Gram-negative pathogens are a rapidly increasing threat to human health worldwide due to
high rates of antibiotic resistance and the lack of development of novel antibiotics. The …

Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donors

M Steenhuis, G van Mierlo, NIL Derksen… - Clinical & …, 2021 - Wiley Online Library
Objectives Characterisation of the human antibody response to SARS‐CoV‐2 infection is
vital for serosurveillance purposes and for treatment options such as transfusion with …

[HTML][HTML] SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and …

D Nguyen, P Simmonds, M Steenhuis… - …, 2021 - eurosurveillance.org
We compared the performance of SARS-CoV-2 neutralising antibody testing between 12
European laboratories involved in convalescent plasma trials. Raw titres differed almost 100 …

SARS-CoV-2 antibodies in adult patients with multiple sclerosis in the Amsterdam MS cohort

ZLE Van Kempen, EMM Strijbis, MMCT Al… - JAMA …, 2021 - jamanetwork.com
Methods| This is a prospective cohort study conducted at the MS Center Amsterdam in
Amsterdam, the Netherlands. On July 31, 2020, all adult patients with a current diagnosis of …

Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

NJM Verstegen, RR Hagen, J van den Dijssel… - Elife, 2022 - elifesciences.org
Background: Patients affected by different types of autoimmune diseases, including common
conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated …

[HTML][HTML] The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

J Van Coillie, T Pongracz, J Rahmöller, HJ Chen… - …, 2023 - thelancet.com
Summary Background Afucosylated IgG1 responses have only been found against
membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These …