User profiles for "author:Mathieu C Tamby"

Mathieu C. Tamby

Researcher, INSERM
Verified email at inserm.fr
Cited by 2345

New insights into the pathogenesis of systemic sclerosis

MC Tamby, Y Chanseaud, L Guillevin, L Mouthon - Autoimmunity reviews, 2003 - Elsevier
Systemic sclerosis (SSc) is a connective tissue disorder characterized by vascular
abnormalities and excessive collagen synthesis. Extracellular matrix overproduction by …

The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension

N Kherbeck, MC Tamby, G Bussone, H Dib… - Clinical reviews in …, 2013 - Springer
Pulmonary arterial hypertension is characterized by a remodeling of pulmonary arteries with
endothelial cell, fibroblast, and vascular smooth muscle cell activation and proliferation …

Pathogenesis of giant cell arteritis: More than just an inflammatory condition?

KH Ly, A Régent, MC Tamby, L Mouthon - Autoimmunity reviews, 2010 - Elsevier
Giant cell arteritis (GCA) is characterized by intimal hyperplasia and luminal obstruction
leading to ischemic manifestations involving extra-cranial branches of carotid arteries and …

Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension

MC Tamby, M Humbert, P Guilpain… - European …, 2006 - Eur Respiratory Soc
The aim of the present study was to investigate the presence of anti-fibroblast antibodies in
patients with idiopathic or scleroderma-associated pulmonary arterial hypertension (PAH) …

Identification of target antigens of antifibroblast antibodies in pulmonary arterial hypertension

B Terrier, MC Tamby, L Camoin, P Guilpain… - American journal of …, 2008 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) may be classified as idiopathic (IPAH) or
familial (FPAH) or associated with various conditions and exposures such as …

Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma

H Dib, MC Tamby, G Bussone, A Regent… - European …, 2012 - Eur Respiratory Soc
Anti-endothelial cell antibodies (AECAs) have been identified in patients with systemic
sclerosis (SSc) with and without pulmonary arterial hypertension (PAH) and in patients with …

Microsomal Prostaglandin E2 Synthase-1 Modulates the Response to Vascular Injury

M Wang, K Ihida-Stansbury, D Kothapalli, MC Tamby… - Circulation, 2011 - Am Heart Assoc
Background—Microsomal (m) prostaglandin (PG) E2 synthase (S)-1 catalyzes the formation
of PGE2 from PGH2, a cyclooxygenase product that is derived from arachidonic acid …

Antifibroblast antibodies from systemic sclerosis patients bind to α-enolase and are associated with interstitial lung disease

B Terrier, MC Tamby, L Camoin, P Guilpain… - Annals of the …, 2010 - ard.bmj.com
Objective: To identify target antigens of antifibroblast antibodies (AFA) in systemic sclerosis
(SSc) patients. Patients and Methods: In the first part, sera from 24 SSc patients (12 with …

[HTML][HTML] Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic …

A Régent, H Dib, KH Ly, C Agard, MC Tamby… - Arthritis research & …, 2011 - Springer
Introduction Immunological studies of giant cell arteritis (GCA) suggest that a triggering
antigen of unknown nature could generate a specific immune response. We thus decided to …

IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction

G Bussone, MC Tamby, C Calzas… - Annals of the …, 2012 - ard.bmj.com
Objectives Pulmonary arterial hypertension (PAH) is characterised by remodelling of
pulmonary arteries with enhanced vascular smooth muscle cell (VSMC) contraction …