Immunocytochemical detection and mapping of a cytokeratin 18 neo‐epitope exposed during early apoptosis
MPG Leers, W Kölgen, V Björklund… - The Journal of …, 1999 - Wiley Online Library
A neo‐epitope in cytokeratin 18 (CK18) that becomes available at an early caspase
cleavage event during apoptosis and is not detectable in vital epithelial cells is …
cleavage event during apoptosis and is not detectable in vital epithelial cells is …
Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm …
S Ramiro, RLM Mostard, C Magro-Checa… - Annals of the …, 2020 - ard.bmj.com
Objectives To prospectively investigate in patients with severe COVID-19-associated
cytokine storm syndrome (CSS) whether an intensive course of glucocorticoids with or …
cytokine storm syndrome (CSS) whether an intensive course of glucocorticoids with or …
Keratin 8/18 breakdown and reorganization during apoptosis
B Schutte, M Henfling, W Kölgen, M Bouman… - Experimental cell …, 2004 - Elsevier
Monoclonal antibodies that specifically recognize caspase cleaved K18 fragments or
specific (phospho) epitopes on intact K8 and K18 were used for a detailed investigation of …
specific (phospho) epitopes on intact K8 and K18 were used for a detailed investigation of …
Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer
MA Sulzer, MPG Leers, JANA van NOORD… - American journal of …, 1998 - atsjournals.org
E-cadherin is a calcium-dependent, epithelial cell adhesion molecule whose reduced
expression has been associated with tumor dedifferentiation and increased lymph node …
expression has been associated with tumor dedifferentiation and increased lymph node …
A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study
J Linssen, A Ermens, M Berrevoets, M Seghezzi… - Elife, 2020 - elifesciences.org
COVID-19 induces haemocytometric changes. Complete blood count changes, including
new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 …
new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 …
The patterns of expression of an apoptosis-related CK18 neoepitope, the bcl-2 proto-oncogene, and the Ki67 proliferation marker in normal, hyperplastic, and …
HM Morsi, MPG Leers, W Jäger… - International journal …, 2000 - journals.lww.com
Expression of a neoepitope on cytokeratin 18, recognized by the monoclonal antibody M30,
is an early indicator of apoptosis in epithelial cells. The aim of this study was to determine …
is an early indicator of apoptosis in epithelial cells. The aim of this study was to determine …
[HTML][HTML] Implementation of novel molecular biomarkers for non-small cell lung cancer in The Netherlands: how to deal with increasing complexity
D Van den Broek, TJN Hiltermann, B Biesma… - Frontiers in …, 2020 - frontiersin.org
The diagnostic landscape of non-small cell lung cancer (NSCLC) is changing rapidly with
the availability of novel treatments. Despite high-level healthcare in the Netherlands, not all …
the availability of novel treatments. Despite high-level healthcare in the Netherlands, not all …
[HTML][HTML] Factor XIa and thrombin generation are elevated in patients with acute coronary syndrome and predict recurrent cardiovascular events
R Loeffen, R van Oerle, MPG Leers, JA Kragten… - PLoS …, 2016 - journals.plos.org
Objective In acute coronary syndrome (ACS) cardiac cell damage is preceded by
thrombosis. Therefore, plasma coagulation markers may have additional diagnostic …
thrombosis. Therefore, plasma coagulation markers may have additional diagnostic …
[HTML][HTML] Severe COVID-19 in inflammatory bowel disease patients in a population-based setting
RH Creemers, A Rezazadeh Ardabili, DM Jonkers… - PLoS …, 2021 - journals.plos.org
Objective Data on the course of severe COVID-19 in inflammatory bowel disease (IBD)
patients remains limited. We aimed to determine the incidence rate and clinical course of …
patients remains limited. We aimed to determine the incidence rate and clinical course of …
Effects of a long-distance run on cardiac markers in healthy athletes
MPG Leers, R Schepers… - Clinical Chemistry and …, 2006 - degruyter.com
Background: Running a marathon is a stressful event for athletes. Limited research exists on
the role of cardiac markers during such a strenuous event. The aim of this study was to …
the role of cardiac markers during such a strenuous event. The aim of this study was to …