Large-scale mapping studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …

Multiple sclerosis (MS) is a complex disease with both genetic variants and environmental
factors involved in disease susceptibility. The main environmental risk factors associated …

Background and Objectives Decreased vitamin D levels and obesity are associated with an
increased risk for multiple sclerosis (MS). However, whether they also affect the disease …

Objectives We explored whether genetically predicted increased body mass index (BMI)
modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling. Methods We …

The immune system is highly diverse, but characterization of its genetic architecture has
lagged behind the vast progress made by genome-wide association studies (GWASs) of …

Objectives Juvenile idiopathic arthritis (JIA) is the most common class of childhood
rheumatic diseases, with distinct disease subsets that may have diverging …

Background Striking changes in the demographic pattern of multiple sclerosis (MS) strongly
indicate an influence of modifiable exposures, which lend themselves well to intervention. It …

Objective Many multiple sclerosis (MS) genetic susceptibility variants have been identified,
but understanding disease heterogeneity remains a key challenge. Relapses are a core …

Objective Evidence for a role of microglia in the pathogenesis of multiple sclerosis (MS) is
growing. We investigated association of microglial markers at time of diagnostic lumbar …

Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and
motor symptoms increase travel burden, and standard neuropsychological tests are not …