Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation

P Viatour, MP Merville, V Bours, A Chariot - Trends in biochemical sciences, 2005 - cell.com
Nuclear factor-κB (NF-κB) is a transcription factor that has crucial roles in inflammation,
immunity, cell proliferation and apoptosis. Activation of NF-κB mainly occurs via IκB kinase …

Nuclear factor-κB, cancer, and apoptosis

V Bours, M Bentires-Alj, AC Hellin, P Viatour… - Biochemical …, 2000 - Elsevier
The role of nuclear factor (NF)-κB in the regulation of apoptosis in normal and cancer cells
has been extensively studied in recent years. Constitutive NF-κB activity in B lymphocytes as …

Multiple redox regulation in NF-kappaB transcription factor activation.

J Piette, B Piret, G Bonizzi, S Schoonbroodt… - Biological …, 1997 - europepmc.org
The well-known Rel/NF-kappaB family of vertebrate transcription factors comprises a
number of structurally related, interacting proteins that bind DNA as dimers and whose …

NF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells

M Bentires-Alj, V Barbu, M Fillet, A Chariot, B Relic… - Oncogene, 2003 - nature.com
The ubiquitous NF-κB transcription factor has been reported to inhibit apoptosis and to
induce drug resistance in cancer cells. Drug resistance is the major reason for cancer …

Reactive oxygen intermediate-dependent NF-κB activation by interleukin-1β requires 5-lipoxygenase or NADPH oxidase activity

G Bonizzi, J Piette, S Schoonbroodt… - … and cellular biology, 1999 - Taylor & Francis
We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-κB
activation by proinflammatory cytokines was cell specific. However, the sources for ROIs in …

The NF-κB transcription factor and cancer: high expression of NF-κB-and IκB-related proteins in tumor cell lines

V Bours, E Dejardin, F Goujon-Letawe… - Biochemical …, 1994 - Elsevier
NF-κB is a pleiotropic transcription factor which controls the expression of many genes and
viruses. To date, there is good evidence, but no difinitive proof, for its role in tumor formation …

[PDF][PDF] Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia

P Close, N Hawkes, I Cornez, C Creppe, CA Lambert… - Molecular cell, 2006 - cell.com
Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a
severe neurodevelopmental disease with complex clinical characteristics. Elongator was …

NF-κB2/p100 induces Bcl-2 expression

P Viatour, M Bentires-Alj, A Chariot, V Deregowski… - Leukemia, 2003 - nature.com
The NF-κB2/p100 and bcl-3 genes are involved in chromosomal translocations described in
chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor …

In vitro and In vivo Activity of the Nuclear Factor-κB Inhibitor Sulfasalazine in Human Glioblastomas

PA Robe, M Bentires-Alj, M Bonif, B Rogister… - Clinical Cancer …, 2004 - AACR
Glioblastomas, the most common primary brain cancers, respond poorly to current treatment
modalities and carry a dismal prognosis. In this study, we demonstrated that the transcription …

Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by interleukin-1

G Bonizzi, J Piette, MP Merville, V Bours - Biochemical pharmacology, 2000 - Elsevier
The role of reactive oxygen intermediates (ROIs) in nuclear factor-kappaB (NF-κB) activation
remains a matter of controversy. We have studied whether ROIs played any role in NF-κB …