Objective The causality and pathogenic mechanism of microbiome composition remain
elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA) …

Human DNA present in faecal samples can result in a small number of human reads in gut
shotgun metagenomic sequencing data. However, it is presently unclear how much …

Objective The relationship between autoimmune diseases and the gut microbiome has been
intensively studied, and several autoimmunity-associated bacterial taxa have been …

Objective Alteration of the gut microbiome has been linked to the pathogenesis of systemic
lupus erythematosus (SLE). However, a comprehensive view of the gut microbiome in SLE …

Summary We reconstructed 19,084 prokaryotic and 31,395 viral genomes from 787
Japanese gut metagenomes as Japanese metagenome-assembled genomes (JMAG) and …

MicroRNAs (miRNAs) modulate the post-transcriptional regulation of target genes and are
related to biology of complex human traits, but genetic landscape of miRNAs remains largely …

Objective To investigate the influence of nutritional status on severe infection complications
in patients with rheumatoid arthritis (RA) Methods This retrospective cohort study on 2108 …

Novel biomarkers of rheumatoid arthritis (RA), in addition to antibodies against cyclic
citrullinated peptides, are required. Metabolome analysis is a promising approach to identify …

A prospective study was made to seek for a convenient biomarker to predict progression of
bone destruction (PBD) in early stages of rheumatoid arthritis (ERA). All participated patients …

Interaction between the gut microbiome and host plays a key role in human health. Here, we
perform a metagenome shotgun-sequencing-based analysis of Japanese participants to …