Simple Summary Cancer metastasis is often associated with a dismal prognosis for the
patient. It is, therefore, crucial to understand the mechanisms behind the cascade of events …

The widely expressed protein Fas is a member of the tumour necrosis factor receptor family
which can trigger apoptosis. However, Fas surface expression does not necessarily render …

Malignant melanoma accounts for most of the increasing mortality from skin cancer.
Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In …

Abstract Background: Activation of Fas (CD95) by its ligand (FasL) rapidly induces cell death
through recruitment and activation of caspase-8 via the adaptor protein Fas-associated …

THE recent generation of perform knock-out mice1, 2 has demonstrated a crucial role for the
pore-forming perforin in cytolytic T-lymphocyte (CTL)-mediated cytolysis. Perforin-deficient …

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses,
including cell growth, differentiation, and even death. Here we describe a novel member of …

Human Fas ligand (L)(CD95L) and tumor necrosis factor (TNF)-α undergo metalloproteinase-
mediated proteolytic processing in their extracellular domains resulting in the release of …

The concept for cellular immunotherapy of solid tumors relies heavily on the capacity of
class I MHC-restricted cytotoxic T lymphocytes (CTLs) to eliminate tumor cells. However …

Programmed cell death plays an important role in the neuronal degeneration after cerebral
ischemia, but the underlying mechanisms are not fully understood. Here we examined, in …

Primary cilia (PC) are antenna‐like organelles that protrude from most mammalian cells.
They are essential for the regulation of several signaling pathways such as Hedgehog and …