OBJECTIVE--To assess the likely importance of matrix metalloproteinases (MMPs) and their
inhibitors (TIMPs) in the arthritic process. METHODS--Synovial samples from seven joints …

BACKGROUND Premature ovarian failure (POF) is a heterogeneous disease defined as
amenorrhoea for> 6 months before age 40, with an FSH serum level> 40 mIU/ml …

Childbirth is a period of substantial rapid biological and psychological change and a wide
range of psychotic disorders can occur ranging from mild 'baby blues' to severe episodes of …

An association analysis using the Illumina porcine SNP60 beadchip was performed to
identify SNPs significantly associated with porcine maternal infanticide. We previously …

Colchicine induced a rapid destruction of the collagenous matrix of pig synovial explants in
culture in the presence of serum. The most efficacious doses were 0.01-0.1 μ/ml (2.5 x 10-8 …

The distribution of the matrix metalloproteinases, collagenase, stromelysin, gelatinases A
and B, and the tissue inhibitor of metalloproteinases in cartilage and synovium removed …

To assess the effects of interleukin-1 on intact articular cartilage in vitro, explants from young
and adult rabbits were cultured with interleukin-1 and the distributions of the matrix …

Aseptic loosening of prosthetic components is the most important long‐term complication of
total joint replacement. To investigate the underlying destructive mechanisms, periprosthetic …

In many pathological situations connective tissue cells acquire the ability to degrade the
macromolecular components of their extracellular matrix. To study the destruction of …

Froyen G, Van Esch H, Bauters M, Hollanders K, Frints SG, Vermeesch JR, Devriendt K,
Fryns JP, Marynen P. Detection of genomic copy number changes in patients with idiopathic …