Two different forms of death are commonly observed when Mycobacterium tuberculosis
(Mtb)-infected macrophages die:(i) necrosis, a death modality defined by cell lysis and (ii) …

Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and
results are starting to come in. Some of these results are not so encouraging, as exemplified …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial
genetic component. Susceptibility to disease has been linked with a region on chromosome …

Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and
depends upon necrosis to elude immunity and disseminate. Although apoptosis of M …

Despite the introduction almost a century ago of Mycobacterium bovis BCG (BCG), an
attenuated form of M. bovis that is used as a vaccine against Mycobacterium tuberculosis …

Abstract Objective Familial Mediterranean fever (FMF) has traditionally been considered an
autosomal‐recessive disease; however, it has been observed that a substantial number of …

Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and
mechanisms of formation remain poorly understood. To understand the role of granulomas …

Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this
protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents …

Objectives Familial Mediterranean fever (FMF) is caused by mutations in MEFV, which
encodes pyrin. The nature of substitutions P369S and R408Q in exon 3 remains unclear …

Supported by National Institutes of Health grant# P01 AI050530 (BSB and LAB); a Fujisawa
American Academy of Allergy, Asthma & Immunology Grant (EC); and an Immunex/Amgen …