The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities
WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
[HTML][HTML] Combination strategies to maximize the benefits of cancer immunotherapy
S Zhu, T Zhang, L Zheng, H Liu, W Song, D Liu… - Journal of hematology & …, 2021 - Springer
Immunotherapies such as immune checkpoint blockade (ICB) and adoptive cell therapy
(ACT) have revolutionized cancer treatment, especially in patients whose disease was …
(ACT) have revolutionized cancer treatment, especially in patients whose disease was …
Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are
transiting rapidly towards clinical applications. However, discrepancies and controversies …
transiting rapidly towards clinical applications. However, discrepancies and controversies …
An efficient one-step site-directed and site-saturation mutagenesis protocol
L Zheng, U Baumann, JL Reymond - Nucleic acids research, 2004 - academic.oup.com
We have developed a new primer design method based on the QuickChange™ site-
directed mutagenesis protocol, which significantly improves the PCR amplification efficiency …
directed mutagenesis protocol, which significantly improves the PCR amplification efficiency …
[PDF][PDF] The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
Follicular helper T (Tfh) cells provide selection signals to germinal center B cells, which is
essential for long-lived antibody responses. High CXCR5 and low CCR7 expression …
essential for long-lived antibody responses. High CXCR5 and low CCR7 expression …
Effect of nano-TiO2 on strength of naturally aged seeds and growth of spinach
L Zheng, F Hong, S Lu, C Liu - Biological trace element research, 2005 - Springer
The effects of nano-TiO 2 (rutile) and non-nano-TiO 2 on the germination and growth of
naturally aged spinach seeds were studied by measuring the germination rate and the …
naturally aged spinach seeds were studied by measuring the germination rate and the …
Joint deep modeling of users and items using reviews for recommendation
A large amount of information exists in reviews written by users. This source of information
has been ignored by most of the current recommender systems while it can potentially …
has been ignored by most of the current recommender systems while it can potentially …
Exosomes‐loaded Electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via Immunoregulation and enhancement of myelinated …
L Fan, C Liu, X Chen, L Zheng, Y Zou, H Wen… - Advanced …, 2022 - Wiley Online Library
Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury
(SCI) repair because they match the electrical and mechanical properties of neural tissue …
(SCI) repair because they match the electrical and mechanical properties of neural tissue …
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
J Fu, DB Kanne, M Leong, LH Glickman… - Science translational …, 2015 - science.org
Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …
[HTML][HTML] S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component
L Zheng, RG Roeder, Y Luo - Cell, 2003 - cell.com
We have isolated and functionally characterized a multicomponent Oct-1 coactivator, OCA-S
which is essential for S phase-dependent histone H2B transcription. The p38 component of …
which is essential for S phase-dependent histone H2B transcription. The p38 component of …