ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches
MC Cleophas, LA Joosten, LK Stamp… - Pharmacogenomics …, 2017 - Taylor & Francis
As a result of the association of a common polymorphism (rs2231142, Q141K) in the ATP-
binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide …
binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide …
[HTML][HTML] Toll-like receptor 2 controls expansion and function of regulatory T cells
…, LWJ Toonen, BJ Kullberg, LA Joosten… - The Journal of …, 2006 - Am Soc Clin Investig
Tregs play a central role in the suppression of immune reactions and prevention of
autoimmune responses harmful to the host. During acute infection, however, Tregs might …
autoimmune responses harmful to the host. During acute infection, however, Tregs might …
[HTML][HTML] The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with …
Introduction IL-1β is a proinflammatory cytokine driving joint inflammation as well as
systemic signs of inflammation, such as fever and acute phase protein production. Methods …
systemic signs of inflammation, such as fever and acute phase protein production. Methods …
TNF alpha and IL-1 beta are separate targets in chronic arthritis.
WB Van den Berg, LA Joosten… - Clinical and …, 1999 - europepmc.org
Chronic arthritis is characterized by persistent joint inflammation and concomitant joint
destruction. Using murine arthritis models and neutralizing antibodies as well as cytokine …
destruction. Using murine arthritis models and neutralizing antibodies as well as cytokine …
Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy
…, MG Netea, LA Joosten… - FEMS microbiology …, 2010 - academic.oup.com
Infections caused by Candida spp. continue to be a substantial cause of disease burden,
especially in immunocompromised patients. New approaches are needed to improve the …
especially in immunocompromised patients. New approaches are needed to improve the …
Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice
…, OH Ramos, FME Segers, LA Joosten… - Biochemical and …, 2009 - Elsevier
Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and
T cells and IL-17 may connect innate and adaptive immune responses involved in …
T cells and IL-17 may connect innate and adaptive immune responses involved in …
Mechanical ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: an in vivomodel using clinical …
…, HB Dijkman, DG Snijdelaar, LA Joosten… - The Journal of the …, 2007 - pubs.asahq.org
Background Mechanical ventilation (MV) may activate the innate immune system, causing
the release of cytokines. The resulting proinflammatory state is a risk factor for ventilator …
the release of cytokines. The resulting proinflammatory state is a risk factor for ventilator …
Low-tidal-volume mechanical ventilation induces a Toll-like receptor 4–dependent inflammatory response in healthy mice
M Vaneker, LA Joosten, LMA Heunks… - The Journal of the …, 2008 - pubs.asahq.org
Background Mechanical ventilation (MV) can induce ventilator-induced lung injury. A role for
proinflammatory pathways has been proposed. The current studies analyzed the roles of …
proinflammatory pathways has been proposed. The current studies analyzed the roles of …
Dual role of IL-12 in early and late stages of murine collagen type II arthritis.
LA Joosten, E Lubberts, MM Helsen… - Journal of Immunology …, 1997 - journals.aai.org
IL-12 can promote Th1 responses, and early administration of IL-12 during immunization
was shown to enhance expression of autoimmune collagen-induced arthritis (CIA). We now …
was shown to enhance expression of autoimmune collagen-induced arthritis (CIA). We now …
[HTML][HTML] Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout
Introduction The acute gout flare results from a localised self-limiting innate immune
response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic …
response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic …