[HTML][HTML] Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
The aim of this study was to determine, through a genome-wide association study (GWAS),
the genetic components contributing to different clinical sub-phenotypes of systemic …
the genetic components contributing to different clinical sub-phenotypes of systemic …
Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus
N Castaño-Rodríguez, LM Diaz-Gallo… - Autoimmunity …, 2008 - Elsevier
OBJECTIVE: To estimate the common effect size of HLA-DRB1 and-DQB1 alleles on
systemic lupus erythematosus (SLE) susceptibility across Latin America populations through …
systemic lupus erythematosus (SLE) susceptibility across Latin America populations through …
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci
Systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are two archetypal
systemic autoimmune diseases which have been shown to share multiple genetic …
systemic autoimmune diseases which have been shown to share multiple genetic …
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies
A Argyriou, B Horuluoglu, AS Galindo‐Feria… - EMBO Molecular …, 2023 - embopress.org
Idiopathic inflammatory myopathies (IIM) are rare autoimmune systemic diseases
characterized by muscle weakness and the presence of muscle‐infiltrating T cells. IIM …
characterized by muscle weakness and the presence of muscle‐infiltrating T cells. IIM …
Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis
LM Diaz-Gallo, L Espino-Paisán… - Inflammatory bowel …, 2011 - academic.oup.com
Background The PTPN22 gene is an important risk factor for human autoimmunity. The aim
of this study was to evaluate for the first time the role of the R263Q PTPN22 polymorphism in …
of this study was to evaluate for the first time the role of the R263Q PTPN22 polymorphism in …
[HTML][HTML] Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to
reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been …
reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been …
Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA‐DRB1 Genotype Associations and Immunological and …
LM Diaz‐Gallo, V Oke, E Lundström… - ACR open …, 2022 - Wiley Online Library
Objective The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and
therapeutical challenges. We therefore studied whether unrecognized disease subgroups …
therapeutical challenges. We therefore studied whether unrecognized disease subgroups …
Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis
LM Diaz-Gallo, P Gourh, J Broen, C Simeon… - Annals of the …, 2011 - ard.bmj.com
Objective Two functional single nucleotide polymorphisms (SNP) in the PTPN22 gene
(rs24746601 and rs33996649) have been associated with autoimmunity. The aim of this …
(rs24746601 and rs33996649) have been associated with autoimmunity. The aim of this …
[HTML][HTML] Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study
OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover
means of predicting which patients would benefit from treatment. However, results have …
means of predicting which patients would benefit from treatment. However, results have …
[HTML][HTML] A gene–environment interaction between smoking and gene polymorphisms provides a high risk of two subgroups of sarcoidosis
NV Rivera, K Patasova, S Kullberg, LM Diaz-Gallo… - Scientific reports, 2019 - nature.com
The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated
gene-environment interaction between multiple genetic variants including HLA genes and …
gene-environment interaction between multiple genetic variants including HLA genes and …