The interferon signature in autoimmune diseases
L Rönnblom, ML Eloranta - Current opinion in rheumatology, 2013 - journals.lww.com
The interferon signature in autoimmune diseases : Current Opinion in Rheumatology The
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …
The innate immune system in SLE: type I interferons and dendritic cells
L Rönnblom, V Pascual - Lupus, 2008 - journals.sagepub.com
Patients with systemic lupus erythematosus (SLE) have an increased expression of type I
interferon (IFN) regulated genes because of a continuous production of IFN-α. The cellular …
interferon (IFN) regulated genes because of a continuous production of IFN-α. The cellular …
A pivotal role for the natural interferon α–producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus
L Rönnblom, GV Alm - The Journal of experimental medicine, 2001 - rupress.org
The human type I IFN gene family consists of 13 genes encoding IFN-α subtypes and one
gene each for IFN-ß and-ω. The type I IFN proteins show similarities with respect to both …
gene each for IFN-ß and-ω. The type I IFN proteins show similarities with respect to both …
[HTML][HTML] Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX
…, M Petri, S Manzi, MF Seldin, L Rönnblom… - … England Journal of …, 2008 - Mass Medical Soc
Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in
which the risk of disease is influenced by complex genetic and environmental contributions …
which the risk of disease is influenced by complex genetic and environmental contributions …
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
…, A Lee, PK Gregersen, MF Seldin, L Rönnblom… - Nature …, 2009 - nature.com
Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
…, L Chen, J Replogle, AC Syvänen, L Rönnblom… - Nature …, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
…, J Blomberg, G Alm, H Vallin, L Rönnblom - Lupus, 2000 - journals.sagepub.com
The objective was to investigate the relation between serum levels of interferon-α (IFN-α),
the activity of an endogenous IFN-a inducing factor (SLE-IIF), clinical and immunological …
the activity of an endogenous IFN-a inducing factor (SLE-IIF), clinical and immunological …
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
…, T Witte, R Jonsson, M Rischmueller, L Rönnblom… - Nature …, 2013 - nature.com
Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …
[PDF][PDF] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
…, K Steinsson, G Alm, L Rönnblom… - The American Journal of …, 2005 - cell.com
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by
both genetic and environmental factors. Genome scans in families with SLE point to multiple …
both genetic and environmental factors. Genome scans in families with SLE point to multiple …
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
…, E Svenungsson, L Rönnblom… - Proceedings of the …, 2007 - National Acad Sciences
Systematic genome-wide studies to map genomic regions associated with human diseases
are becoming more practical. Increasingly, efforts will be focused on the identification of the …
are becoming more practical. Increasingly, efforts will be focused on the identification of the …