Metabolism and the control of cell fate decisions and stem cell renewal

K Ito, K Ito - Annual review of cell and developmental biology, 2016 - annualreviews.org
Although the stem cells of various tissues remain in the quiescent state to maintain their
undifferentiated state, they also undergo cell divisions as required, and if necessary, even a …

[HTML][HTML] Hematopoietic stem cell fate through metabolic control

K Ito, K Ito - Experimental hematology, 2018 - Elsevier
Highlights•Specific modes of metabolism play important roles in hematopoietic stem cell
(HSC) self-renewal.•Heterogeneity and technical challenges have prevented the elucidation …

Glutamate receptors: RNA editing and death of motor neurons.

Y Kawahara, K Ito, H Sun, H Aizawa, I Kanazawa… - Nature, 2004 - go.gale.com
The aetiology of sporadic amyotrophic lateral sclerosis (ALS), a fatal paralytic disease, is
largely unknown. Here we show that there is a defect in the editing of the messenger RNA …

Dose–response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

R Tagawa, D Watanabe, K Ito, K Ueda… - Nutrition …, 2021 - academic.oup.com
Context Lean body mass is essential for health, yet consensus regarding the effectiveness of
protein interventions in increasing lean body mass is lacking. Objective The aim of this …

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

K Ito, R Turcotte, J Cui, SE Zimmerman, S Pinho… - Science, 2016 - science.org
A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and
maintaining homeostasis by balancing self-renewal and cell differentiation. The …

Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources

H Ohara, H Matsumoto, K Ito, K Iwai… - Journal of agricultural …, 2007 - ACS Publications
We compared quantity and structures of food-derived gelatin hydrolysates in human blood
from three sources of type I collagen in a single blind crossover study. Five healthy male …

Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: interim analysis of 3881 patients

T Koike, M Harigai, S Inokuma, N Ishiguro… - Annals of the …, 2011 - ard.bmj.com
Objective An interim analysis of an all-patient postmarketing surveillance programme in
Japan to investigate the safety of tocilizumab for the treatment of rheumatoid arthritis (RA) in …

Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions

N Nishimoto, K Ito, N Takagi - Modern rheumatology, 2010 - academic.oup.com
We present safety and efficacy data from Japanese clinical studies on monotherapy with
tocilizumab (TCZ), a humanized anti-interleukin 6 receptor monoclonal antibody, in which …

Segmenting lung fields in serial chest radiographs using both population-based and patient-specific shape statistics

Y Shi, F Qi, Z Xue, L Chen, K Ito… - IEEE Transactions on …, 2008 - ieeexplore.ieee.org
This paper presents a new deformable model using both population-based and patient-
specific shape statistics to segment lung fields from serial chest radiographs. There are two …

Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues

H Matsumoto, Y Nakamura, H Iida, K Ito… - Experimental eye …, 2006 - Elsevier
Anthocyanins (ACs) are phenolic compounds that are distributed widely in fruits and
vegetables. Although consumption of these compounds has been shown to improve visual …