Crucial role of visfatin/pre–B cell colony‐enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis
M Gosset, F Berenbaum, C Salvat… - Arthritis & …, 2008 - Wiley Online Library
Abstract Objective Prostaglandin E2 (PGE2) is one of the main catabolic factors involved in
osteoarthritis (OA), and metalloproteinases (MMPs) are crucial for cartilage degradation …
osteoarthritis (OA), and metalloproteinases (MMPs) are crucial for cartilage degradation …
Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts
Background Cognitive decline is a debilitating manifestation of disease progression in
Parkinson's disease. We aimed to develop a clinical–genetic score to predict global …
Parkinson's disease. We aimed to develop a clinical–genetic score to predict global …
The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice
S Alves, F Cormier-Dequaire, M Marinello… - Acta …, 2014 - Springer
There is still no treatment for polyglutamine disorders, but clearance of mutant proteins might
represent a potential therapeutic strategy. Autophagy, the major pathway for organelle and …
represent a potential therapeutic strategy. Autophagy, the major pathway for organelle and …
Dopa-decarboxylase gene polymorphisms affect the motor response to L-dopa in Parkinson's disease
D Devos, S Lejeune, F Cormier-Dequaire… - Parkinsonism & related …, 2014 - Elsevier
Abstract Background In Parkinson's disease (PD), the response to l-dopa is highly variable
and unpredictable. The major pathway for dopamine synthesis from l-dopa is …
and unpredictable. The major pathway for dopamine synthesis from l-dopa is …
Early cognitive decline after bilateral subthalamic deep brain stimulation in Parkinson's disease patients with GBA mutations
G Mangone, S Bekadar, F Cormier-Dequaire… - Parkinsonism & Related …, 2020 - Elsevier
Background Subthalamic nucleus deep brain stimulation (STN-DBS) has demonstrated its
efficacy on motor complications in advanced Parkinson's disease (PD) but does not modify …
efficacy on motor complications in advanced Parkinson's disease (PD) but does not modify …
Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia
F Charbonnier-Beaupel, M Malerbi… - Journal of …, 2015 - Soc Neuroscience
In Parkinson's disease, long-term dopamine replacement therapy is complicated by the
appearance of l-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results …
appearance of l-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results …
The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism
The catechol-O-methyltranferase (COMT) is one of the main enzymes that metabolise
dopamine in the brain. The Val158Met polymorphism in the COMT gene (rs4680) causes a …
dopamine in the brain. The Val158Met polymorphism in the COMT gene (rs4680) causes a …
Activation of the peroxisome proliferator–activated receptor α pathway potentiates interleukin‐1 receptor antagonist production in cytokine‐treated chondrocytes
M François, P Richette, L Tsagris, C Fitting… - Arthritis & …, 2006 - Wiley Online Library
Objective To determine whether peroxisome proliferator–activated receptor α (PPARα)
agonists protect chondrocytes against the effects of interleukin‐1β (IL‐1β). Methods PPARα …
agonists protect chondrocytes against the effects of interleukin‐1β (IL‐1β). Methods PPARα …
Oestrogens inhibit interleukin 1β-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-κB impairment
P Richette, MF Dumontier, K Tahiri… - Annals of the …, 2007 - ard.bmj.com
Objectives: To investigate the presence and functionality of oestrogen receptor α (ERα) in
interleukin (IL) 1β-treated rabbit articular chondrocytes in culture, and to determine the …
interleukin (IL) 1β-treated rabbit articular chondrocytes in culture, and to determine the …
SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models
M Marinello, A Werner, M Giannone… - Disease models & …, 2019 - journals.biologists.com
Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause
of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar …
of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar …