Nrf2, a member of the “cap 'n collar” group of transcription factors, is important for protecting
cells against oxidative damage. We investigated its role in the detoxification of …

The antioxidant responsive element (ARE) mediates transcriptional regulation of phase II
detoxification enzymes and antioxidant proteins such as NAD (P) H: quinone …

The locus control region of the β-globin gene is composed of four erythroid-specific
hypersensitive sites. Hypersensitive site 2 has been shown to be a powerful enhancer and …

Nrf2 is a member of the “cap 'n'collar” family of transcription factors. These transcription
factors bind to the NF-E2 binding sites (GCTGAGTCA) that are essential for the regulation of …

Keratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes
survival of these cells under stress conditions. In a search for KGF-regulated genes in …

Objectives Increasing evidence suggests that oxidative stress may play a key role in joint
destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of …

Complex II inhibitors 3-nitropropionic acid (3NP) and malonate cause striatal damage
reminiscent of Huntington's disease and have been shown to involve oxidative stress in their …

A basic leucine zipper transcription factor, NF-E2-related factor 2 (Nrf2), plays a critical role
in the cellular defense mechanism by mediating a coordinate up-regulation of antioxidant …

A 1.6-kilobase pair full-length cDNA encoding a transcription factor homologous to the Maf
family of proteins was isolated by screening a K562 cDNA library with the NFE2 tandem …

Isolation and mapping of a mouse complementary DNA sequence (mouse Y-finger)
encoding a multiple, potential zinc-binding, finger protein homologous to the candidate …