Tumour necrosis factor (TNF), a cytokine mainly produced by macrophages, is associated
with a broad spectrum of biological effects, mainly associated with the host defense against …

To date, the available options to treat autoimmune diseases such as rheumatoid arthritis
(RA) include traditional corticoids and biological drugs, which are not exempt of adverse …

Introduction Several molecules help preserve peripheral B cell tolerance, but when altered,
they may predispose to autoimmunity. This work studied the expression of the costimulatory …

Several studies have demonstrated that diabetes is a risk factor for developing periodontal
disease, increasing its prevalence and severity. Furthermore, periodontitis may impair the …

There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential
target for immunotherapy. However, the molecular bases that drive the differentiation of …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects 0.8% of the world
population, it affects the synovial membrane of joints and the clinical presentation …

Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated
autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and …

Several single-nucleotide polymorphisms (SNPs) have been identified in the TNF-α gene
promoter. The transition G→ A at position–308 generates the TNF-α1 (G/G) and TNF-α2 (G/A …

OBJECTIVE: To assess the enzymatic activity and biochemical status of dipeptidyl peptidase
IV (DPP IV), an enzyme that participates in the degradation of proinflammatory molecules, in …

Objective Rheumatoid arthritis (RA) immunopathogenesis revolves around the presentation
of poorly characterised self-peptides by human leucocyte antigen (HLA)-class II molecules …