[HTML][HTML] Genome-wide pathway analysis identifies genetic pathways associated with psoriasis
Psoriasis is a chronic inflammatory disease with a complex genetic architecture. To date, the
psoriasis heritability is only partially explained. However, there is increasing evidence that
the missing heritability in psoriasis could be explained by multiple genetic variants of low
effect size from common genetic pathways. The objective of this study was to identify new
genetic variation associated with psoriasis risk at the pathway level. We genotyped 598,258
single nucleotide polymorphisms in a discovery cohort of 2,281 case-control individuals from …
psoriasis heritability is only partially explained. However, there is increasing evidence that
the missing heritability in psoriasis could be explained by multiple genetic variants of low
effect size from common genetic pathways. The objective of this study was to identify new
genetic variation associated with psoriasis risk at the pathway level. We genotyped 598,258
single nucleotide polymorphisms in a discovery cohort of 2,281 case-control individuals from …
Genome-wide pathway analysis identifies genetic pathways associated with psoriasis
A Aterido Ballonga, A Julià, C Ferrándiz… - … . 2016 Mar; 136 (3) …, 2016 - repositori.upf.edu
Psoriasis is a chronic inflammatory disease with a complex genetic architecture. To date, the
psoriasis heritability is only partially explained. However, there is increasing evidence that
the missing heritability in psoriasis could be explained by multiple genetic variants of low
effect size from common genetic pathways. The objective of this study was to identify new
genetic variation associated with psoriasis risk at the pathway level. We genotyped 598,258
single nucleotide polymorphisms in a discovery cohort of 2,281 case-control individuals from …
psoriasis heritability is only partially explained. However, there is increasing evidence that
the missing heritability in psoriasis could be explained by multiple genetic variants of low
effect size from common genetic pathways. The objective of this study was to identify new
genetic variation associated with psoriasis risk at the pathway level. We genotyped 598,258
single nucleotide polymorphisms in a discovery cohort of 2,281 case-control individuals from …
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