Polycystic ovary syndrome

R Azziz, E Carmina, ZJ Chen, A Dunaif… - Nature reviews Disease …, 2016 - nature.com
Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide.
The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic …

Ultrasound assessment of the polycystic ovary: international consensus definitions

AH Balen, JSE Laven, SL Tan… - Human reproduction …, 2003 - academic.oup.com
The polycystic ovary syndrome (PCOS) is a heterogeneous condition, the pathophysiology
of which appears to be both multifactorial and polygenic. The definition of the syndrome has …

[HTML][HTML] Anti-Mullerian hormone: a new marker for ovarian function

JA Visser, FH de Jong, JSE Laven… - …, 2006 - rep.bioscientifica.com
Anti-Müllerian hormone (AMH) is a member of the transforming growth factor β family of
growth and differentiation factors. In the ovary, AMH has an inhibitory effect on primordial …

[HTML][HTML] Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop …

BCJM Fauser, BC Tarlatzis, RW Rebar, RS Legro… - Fertility and sterility, 2012 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with
a high prevalence. The etiology of this heterogeneous condition remains obscure, and its …

Anti‐Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment

C Weenen, JSE Laven, ARM Von Bergh… - Molecular human …, 2004 - academic.oup.com
Anti‐Müllerian hormone (AMH) is a member of the transforming growth factor‐β superfamily,
which plays an important role in both ovarian primordial follicle recruitment and dominant …

[HTML][HTML] Antimüllerian hormone serum levels: a putative marker for ovarian aging

A de Vet, JSE Laven, FH de Jong, APN Themmen… - Fertility and sterility, 2002 - Elsevier
Objective: To investigate whether serum concentrations of antimüllerian hormone may be
used as a marker for ovarian aging. Design: Longitudinal observational study. Setting …

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

CE Elks, JRB Perry, P Sulem, DI Chasman… - Nature …, 2010 - nature.com
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

FR Day, DJ Thompson, H Helgason, DI Chasman… - Nature …, 2017 - nature.com
The timing of puberty is a highly polygenic childhood trait that is epidemiologically
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …

Anti-Mullerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age

JSE Laven, AG Mulders, JA Visser… - The Journal of …, 2004 - academic.oup.com
Anti-Müllerian hormone (AMH) concentrations correlate with the number of antral follicles
as well as age and constitute an endocrine marker for ovarian aging. In normogonadotropic …

Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications

SL Broer, FJM Broekmans, JSE Laven… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND In women, anti-Müllerian hormone (AMH) is exclusively produced by
granulosa cells of ovarian follicles during the early stages of follicle development. After an …