Context Denosumab discontinuation is characterized by an increase in bone turnover
overriding pretreatment status, a rapid bone loss in the majority and multiple vertebral …

Hypercalcaemia is a common finding in the setting of primary care, 1 as well as in
emergency departments2 and patients admitted to hospital. 3 Primary hyperparathyroidism …

Abstract Tumour-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a
rare paraneoplastic disorder caused by tumours that secrete fibroblast growth factor 23 …

Context: The fourth International Workshop on the Management of Asymptomatic Primary
Hyperparathyroidism (PHPT) has recently suggested that skeletal and renal imaging be …

BACKGROUND: Patients with primary hyperparathyroidism (PHPT) generally show reduced
bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone …

Data on cardiovascular disease in primary hyperparathyroidism (PHPT) are controversial;
indeed, at present, cardiovascular involvement is not included among the criteria needed for …

The multiple endocrine functions of bone other than those related to mineral metabolism,
such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have …

The aim of this clinical narrative review is to summarize and critically appraise the literature
on the differential diagnosis of hypocalcemia and to provide its correct management …

Context Antiresorptive therapy significantly reduces fracture risk in patients with benign bone
disease and skeletal-related events (SREs) in patients with bone metastases (BM) …

The skin synthesis of vitamin D represents the first step of a metabolic pathway whose
features have been extensively studied and clarified in the last decades. In particular, the …