An international registry on autoinflammatory diseases: the Eurofever experience

N Toplak, J Frenkel, S Ozen, HJ Lachmann… - Annals of the …, 2012 - ard.bmj.com
Objective To report on the demographic data from the first 18 months of enrollment to an
international registry on autoinflammatory diseases in the context of the Eurofever project …

Tumor necrosis factor-alpha blocker in treatment of juvenile idiopathic arthritis-associated uveitis refractory to second-line agents: results of a multinational survey.

I Foeldvari, S Nielsen, J Kümmerle-Deschner… - The Journal of …, 2007 - jrheum.org
OBJECTIVE: Uveitis occurs in 10%-15% of patients with juvenile idiopathic arthritis (JIA). If
topical treatment fails, second-line agents are used to control the disease. However, some …

[HTML][HTML] Localization and functionality of the inflammasome in neutrophils

M Bakele, M Joos, S Burdi, N Allgaier, S Pöschel… - Journal of Biological …, 2014 - ASBMB
Neutrophils represent the major fraction of circulating immune cells and are rapidly recruited
to sites of infection and inflammation. The inflammasome is a multiprotein complex that …

Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

X Liu, T Pichulik, OO Wolz, TM Dang, A Stutz… - Journal of Allergy and …, 2017 - Elsevier
Background The Nod-like receptor NACHT, LRR, and PYD domain–containing protein 3
(NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and adaptive immunity …

MRI findings in psoriatic arthritis of the hands

D Spira, I Kötter, J Henes… - American Journal of …, 2010 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this essay is to provide a practical review of the spectrum of
morphologic and functional MRI findings in psoriatic arthritis of the hand joints …

Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial

AV Ramanan, P Quartier, N Okamoto, I Foeldvari… - The Lancet, 2023 - thelancet.com
Background Juvenile idiopathic arthritis can be refractory to some or all treatment regimens,
therefore new medications are needed to treat this population. This trial assessed the …

Localized scleroderma: MR findings and clinical features

S Schanz, G Fierlbeck, A Ulmer, M Schmalzing… - Radiology, 2011 - pubs.rsna.org
Purpose To describe musculoskeletal manifestations seen at magnetic resonance (MR)
imaging in patients with localized scleroderma (LS) and to examine the relationship of MR …

Efficacy and safety of etanercept in patients with the enthesitis‐related arthritis category of juvenile idiopathic arthritis: results from a phase III randomized, double …

G Horneff, I Foeldvari, K Minden… - Arthritis & …, 2015 - Wiley Online Library
Objective To evaluate the efficacy and safety of etanercept in patients with enthesitis‐related
arthritis (ERA) in juvenile idiopathic arthritis (JIA). Methods This was a 2‐phase study in JIA …

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

ZA Bittner, X Liu, M Mateo Tortola… - Journal of Experimental …, 2021 - rupress.org
Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by
accessory proteins, posttranslational modifications, cellular localization, and …

Risk factors for severe Muckle‐Wells syndrome

JB Kümmerle‐Deschner, PN Tyrrell… - Arthritis & …, 2010 - Wiley Online Library
Abstract Objective Muckle‐Wells syndrome (MWS) is an inherited autoinflammatory disease
resulting in excessive interleukin‐1 release. It is unknown whether demographic, clinical, or …