IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with …
TB Niewold, JA Kelly, SN Kariuki, BS Franek… - Annals of the …, 2012 - ard.bmj.com
Objective High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus
erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can …
erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can …
IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency
By inhibition of JAK-STAT signaling, SOCS1 acts as a master regulator of the cytokine
response across numerous tissue types and cytokine pathways. Haploinsufficiency of …
response across numerous tissue types and cytokine pathways. Haploinsufficiency of …