The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

J Sellam, F Berenbaum - Nature Reviews Rheumatology, 2010 - nature.com
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

The role of metabolism in the pathogenesis of osteoarthritis

A Mobasheri, MP Rayman, O Gualillo… - Nature Reviews …, 2017 - nature.com
Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis

K Louati, C Vidal, F Berenbaum, J Sellam - RMD open, 2015 - rmdopen.bmj.com
Objectives To investigate the prevalence of osteoarthritis (OA) in patients with diabetes
mellitus (DM) and prevalence of DM in patients with OA and whether OA and DM are …

Is osteoarthritis a metabolic disease?

J Sellam, F Berenbaum - Joint bone spine, 2013 - Elsevier
Obesity, together with aging and injury, is among the main risk factors for osteoarthritis.
Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the …

[HTML][HTML] B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary …

M Ittah, C Miceli-Richard, J Eric Gottenberg… - Arthritis research & …, 2006 - Springer
B cell-activating factor (BAFF) has a key role in promoting B-lymphocyte activation and
survival in primary Sjögren's syndrome (pSS). The cellular origin of BAFF overexpression in …

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

M Rosenzwajg, R Lorenzon, P Cacoub… - Annals of the …, 2019 - ard.bmj.com
Objective Regulatory T cells (Tregs) prevent autoimmunity and control inflammation.
Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low …

[HTML][HTML] Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease …

J Sellam, V Proulle, A Jüngel, M Ittah… - Arthritis research & …, 2009 - Springer
Introduction Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich
microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell …

[HTML][HTML] Metabolic stress-induced joint inflammation and osteoarthritis

A Courties, O Gualillo, F Berenbaum, J Sellam - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them,
obesity has a major impact on both loading and non-loading joints. Mechanical overload …

Metabolic syndrome-associated osteoarthritis

A Courties, J Sellam, F Berenbaum - Current opinion in …, 2017 - journals.lww.com
Metabolic syndrome-associated osteoarthritis : Current Opinion in Rheumatology Metabolic
syndrome-associated osteoarthritis : Current Opinion in Rheumatology Log in or Register …

Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid …

M Dougados, S Jousse-Joulin, F Mistretta… - Annals of the …, 2010 - ard.bmj.com
Objectives To evaluate different global ultrasonographic (US) synovitis scoring systems as
potential outcome measures of rheumatoid arthritis (RA) according to the Outcome …