Insights from prospective, longitudinal studies of individuals at risk for developing type 1
diabetes have demonstrated that the disease is a continuum that progresses sequentially at …

Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

The treatment of malignant brain tumors in infants and very young children: An update of the
Pediatric Oncology in Group experie Page 1 Neuro-Oncology APRIL 1999 152 The treatment …

The development of the microbiome from infancy to childhood is dependent on a range of
factors, with microbial–immune crosstalk during this time thought to be involved in the …

Background Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in
women; it is associated with inappropriate activation of mammalian target of rapamycin …

Background Type 1 diabetes is a chronic autoimmune disease that leads to destruction of
insulin-producing beta cells and dependence on exogenous insulin for survival. Some …

Background Among patients with malignant brain tumors, infants and very young children
have the worst prognosis and the most severe treatment-related neurotoxic effects …

BACKGROUND It is believed that BRCA1 and BRCA2 germline mutations account for the
majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are …

Background The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell
autoimmunity. To be fully active, immune T cells need a co-stimulatory signal in addition to …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta
cells and incorporates genetic and environmental factors, including complex genetic …