ASHERSON, RONALD AMD, FACP, FCP,(SA) 1; KHAMASHTA, MUNTHER AMD 1; ORDI-
ROS, JOSE MD 3; DERKSEN, RONALD HWMMD 2; MACHIN, SAMUEL JMD, FRC PATH. 4; …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown aetiology with a
complex genetic basis that includes many susceptibility genes on multiple chromosomes. As …

Eight per cent of the human genome is derived from the integration of retroviral sequences
that were incorporated in our DNA more than 25 million years ago. Although some of these …

Retroviruses can exist in an endogenous form, in which viral sequences are integrated into
the human germ line and are vertically transmitted in a Mendelian fashion. Human …

Abstract purpose: To determine whether the features of the antiphospholipid syndrome
(APS) are in any way influenced by the presence or absence of systemic lupus …

Objective. Our aim was to assess the outcome of pregnancy in a cohort of patients with SLE
and to evaluate clinical and laboratory markers for fetal outcome and maternal flares …

Background: The potential role of new oral anticoagulants in antiphospholipid antibody
syndrome (APS) remains uncertain. Objective: To determine whether rivaroxaban is …

Background Despite overall improvement in prognosis, 10–30% of patients with lupus
nephritis (LN) will develop end-stage renal disease. To date, renal biopsy is still the 'gold …

Introduction We aimed to replicate association of newly identified systemic lupus
erythematosus (SLE) loci. Methods We selected the most associated SNP in 10 SLE loci …

Objective. To examine the potential immunologic mechanism and involvement of antiphos
pholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphos …