Bone is constantly being remodelled in a dynamic process where osteoblasts are
responsible for bone formation and osteoclasts for its resorption. Osteoblasts are specialized …

Osteoimmunology is an emerging field of research dedicated to the investigation of the
interactions between the immune and skeletal systems. These interactions are not only …

Bone histomorphometry is defined as a quantitative evaluation of bone micro architecture,
remodelling and metabolism. Bone metabolic assessment is based on a dynamic process …

We recently developed base editing, a genome-editing approach that enables the
programmable conversion of one base pair into another without double-stranded DNA …

Objective. To characterize circulating B-cell subpopulations of arthritis patients with< 6
weeks of disease duration. Methods. Peripheral blood samples were collected from very …

Objectives. To analyse the activation state and apoptosis of circulating neutrophils in
untreated very early rheumatoid arthritis (VERA) and after exposure to low dose …

Background Fracture healing is orchestrated by a specific set of events that culminates in the
repair of bone and reachievement of its biomechanical properties. The aim of our work was …

Objective. The association of non-MHC genes with AS has been recently suggested. We
aimed to investigate the association of the ERAP1, IL23R and TNFSF15 regions and the …

The objective of this study was to assess whether clinical measures of rheumatoid arthritis
activity and severity were influenced by tumor necrosis factor-alpha (TNF-α) promoter …

Introduction In this study we used a mice model of chronic arthritis to evaluate if bone fragility
induced by chronic inflammation is associated with an imbalance in bone turnover and also …