User profiles for "author:Irene Rosa"

Irene Rosa

PhD, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze
Verified email at unifi.it
Cited by 2032

Telocytes: an emerging component of stem cell niche microenvironment

I Rosa, M Marini, M Manetti - Journal of Histochemistry & …, 2021 - journals.sagepub.com
Telocytes (TCs) are newly identified interstitial cells characterized by thin and long
cytoplasmic processes, called telopodes, which exhibit a distinctive moniliform shape and …

Telocyte implications in human pathology: An overview

L Ibba-Manneschi, I Rosa, M Manetti - Seminars in Cell & Developmental …, 2016 - Elsevier
Telocytes are a recently described interstitial cell population widely distributed in the stromal
compartment of many organs in vertebrates, including humans. Owing to their close spatial …

Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis

M Manetti, E Romano, I Rosa, S Guiducci… - Annals of the …, 2017 - ard.bmj.com
Objective Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly
by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a …

[HTML][HTML] Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis

I Rosa, E Romano, BS Fioretto… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
Adipose-derived stem cells (ADSCs) residing in the stromal vascular fraction (SVF) of white
adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in …

Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis

M Manetti, S Guiducci, M Ruffo, I Rosa… - Journal of cellular …, 2013 - Wiley Online Library
Telocytes, a peculiar type of stromal cells, have been recently identified in a variety of
tissues and organs, including human skin. Systemic sclerosis (SS c, scleroderma) is a …

Telocytes in Crohn's disease

AF Milia, M Ruffo, M Manetti, I Rosa… - Journal of cellular …, 2013 - Wiley Online Library
Crohn's disease (CD) is a relapsing chronic inflammatory disorder that may involve all the
gastrointestinal tract with a prevalence of terminal ileum. Intestinal lesions have a …

A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis

M Manetti, I Rosa, L Messerini… - Journal of cellular …, 2014 - Wiley Online Library
Systemic sclerosis (SS c) is a complex connective tissue disease characterized by fibrosis of
the skin and various internal organs. In SS c, telocytes, a peculiar type of stromal (interstitial) …

Telocytes are reduced during fibrotic remodelling of the colonic wall in ulcerative colitis

M Manetti, I Rosa, L Messerini… - Journal of cellular …, 2015 - Wiley Online Library
Ulcerative colitis (UC) is characterized by chronic relapsing intestinal inflammation finally
leading to extensive tissue fibrosis and resulting in a stiff colon unable to carry out peristalsis …

Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new …

M Manetti, I Rosa, AF Milia, S Guiducci… - Annals of the …, 2014 - ard.bmj.com
Objective Urokinase-type plasminogen activator receptor (uPAR) is a key component of the
fibrinolytic system involved in extracellular matrix remodelling and angiogenesis. The …

[HTML][HTML] Reappraising the microscopic anatomy of human testis: identification of telocyte networks in the peritubular and intertubular stromal space

M Marini, I Rosa, D Guasti, M Gacci, E Sgambati… - Scientific reports, 2018 - nature.com
Telocytes are a recently described stromal cell type widely distributed in various organs
including the female and male reproductive systems. This study was aimed to investigate for …