A large number of changes, distant from the site or sites of inflammation and involving many
organ systems, may accompany inflammation. In 1930 interest was focused on these …

The maintenance of physiologic homeostasis during the ups and downs of daily living is
assured by a number of physiologic mechanisms. From time to time, however, perturbing …

C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein, with
homologs in vertebrates and many invertebrates, that participates in the systemic response …

Reports of the predictive value of minor elevation of serum C-reactive protein (CRP) levels
(between 3 and 10 mg/L) for atherosclerotic events have generated considerable interest, as …

The Acute Phase Response During good health, when there are no substantial threats to
body integrity, our homeostatic mechanisms maintain an optimal internal environment in the …

In order to investigate the magnitude and kinetics of the C-reactive protein (CRP) response
after differing degrees of tissue injury, we studied changes in serum concentration of this …

Interleukin-6 (IL-6) is the major cytokine inducing transcription of human C-reactive protein
(CRP) during the acute phase response. STAT (signal transducers and activators of …

We describe, in Ethiopia, a third successful pattern of human adaptation to high-altitude
hypoxia that contrasts with both the Andean “classic”(erythrocytosis with arterial hypoxemia) …

We evaluated the effects of binary combinations of four cytokines on production of the
positive acute phase proteins alpha-1 antichymotrypsin, haptoglobin and fibrinogen, and the …

To determine the cell of origin of C-reactive protein (CRP) and to cast light on the
mechanisms leading to the acute phase response, we used an immunoenzymatic technique …