Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …

Objectives The study of the proinflammatory role of uric acid has focused on the effects of its
crystals of monosodium urate (MSU). However, little is known whether uric acid itself can …

Objectives Acute gouty arthritis is caused by endogenously formed monosodium urate
(MSU) crystals, which are potent activators of the NLRP3 inflammasome. However, to induce …

Objective. Adipocytokines, including leptin and adiponectin, may play an important role in
the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of longterm …

Background Inflammation and coagulation are key processes in cardiovascular diseases
(CVDs). The Canakinumab Anti-inflammatory Thrombosis Outcome Study trial affirmed the …

We evaluated six precipitation methods for high-density lipoprotein cholesterol (HDL-chol)
determination: the heparin/Mn2+ precipitation reagent method (Hep), two variants of the …

corresponding DR values (Fig. 1C). PRA results from the 6 h-incubation assay correlated
strongly (r 0.98) with corresponding 3-h corresponding DR values (Fig. 1C). PRA results …

Background and methods Platelets are key cells in coagulation and inflammation and as
such play an important role in the development of ischemic cardiovascular diseases (CVD) …

Adipocytokines, including leptin and adiponectin, may play an important role in the
pathogenesis of rheumatoid arthritis (RA) The effects of long-term therapeutic TNF blockade …