In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …

Unravelling spatio-temporal patterns of gene expression is crucial to understanding core
biological principles from embryogenesis to disease. Here we review emerging …

The growth and progression of solid tumors involves dynamic cross-talk between cancer
epithelium and the surrounding microenvironment. To date, molecular profiling has largely …

Spatially adjacent habitats on coral reefs can represent highly distinct environments, often
harbouring different coral communities. Yet, certain coral species thrive across divergent …

Background Treat-to-target strategies have improved outcomes in single-organ diseases
with simple clinical or laboratory endpoints. A lack of validated endpoints has prevented …

Organ growth requires a careful balance between stem cell self-renewal and lineage
commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that …

Organ fibroblasts are essential components of homeostatic and diseased tissues. They
participate in sculpting the extracellular matrix, sensing the microenvironment, and …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the
respiratory tract, but pulmonary and cardiac complications occur in severe coronavirus …

Objective Disease severity in SLE is an important concept related to disease activity,
treatment burden and prognosis. We set out to evaluate if high disease activity status …

Background Gene ontology (GO) enrichment analysis is frequently undertaken during
exploration of various-omics data sets. Despite the wide array of tools available to biologists …