Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining
genetic risk factors and autoantibodies, sub-classified into ACPA-positive and-negative RA …

There is convincing evidence for the known and unambiguously accepted beneficial effects
of glucocorticoids at low dosages. However, the implementation of existing …

The immune response to citrullinated antigens is found almost exclusively in patients with
rheumatoid arthritis (RA). It is a dynamic response that expands before the onset of disease …

Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most
severe inflammatory joint disease, autoantibodies against citrullinated proteins are among …

The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …

Peptides associated with the heat shock protein gp96 induce a specific T cell response
against cells from which gp96 is isolated. Recently, we have shown that gp96 binds to a yet …

Objective To determine whether anticitrullinated protein antibodies (ACPA) exhibit specific
changes in Fc glycosylation prior to the onset of arthritis. Methods Serum samples of patients …

Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the
engagement of pro-or anti-inflammatory Fcγ receptors (FcγR) and the direction of the …

Objective Anti–citrullinated protein antibodies (ACPA) exhibit unique specificity for
rheumatoid arthritis. However, it is incompletely understood whether and how ACPA …

Objectives To understand the molecular features distinguishing anti-citrullinated protein
antibodies (ACPA) from 'conventional'antibodies in rheumatoid arthritis (RA). Methods …