The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas
of the developing lung (LungMAP) to serve as a research resource and public education …

Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems
have led to new physiologically complex in vitro models to study human development and …

Heart valve disease is an important cause of morbidity and mortality worldwide. Little is
known about valve disease pathogenesis, but increasing evidence implicates a genetic …

Rationale: Considerable confusion exists regarding nomenclature, classification, and
management of pediatric diffuse lung diseases due to the relative rarity and differences in …

Lung morphogenesis requires the integration of multiple regulatory factors, which results in
a functional air-blood interface required for gas exchange at birth. The respiratory tract is …

Cell fate and morphogenesis within the embryo is dependent upon secreted molecules that
transduce signals between neighboring tissues. Reciprocal mesenchymal-epithelial …

OBJECTIVE: Childhood interstitial lung diseases (ILD) occur in a variety of clinical contexts.
Advances in the understanding of disease pathogenesis and use of standardized …

Objective To investigate the characteristics and risk factors of a novel parenchymal lung
disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). Methods In …

OBJECTIVE. Neuroendocrine cell hyperplasia of infancy is a form of childhood interstitial
lung disease originally reported as persistent tachypnea of infancy. Reports of small series …

Background The diagnostic gold standard for neuroendocrine cell hyperplasia of infancy
(NEHI) is demonstration of increased numbers of neuroendocrine cells (NECs) amid …