Migraine remains an elusive and poorly understood disease. The uncertainty is reflected by
the currently unsatisfactory acute and prophylactic treatments for this disease. Genetic and …

Multiple sclerosis (MS) is a chronic neurodegenerative and autoimmune disease. Motor,
sensory and cognitive deficits in MS are commonly accompanied by psychiatric disorders …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …

Despite intense investigation, the mechanisms of the different forms of trigeminal
neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 …

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by
nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and painful adverse
reaction of cancer treatment in patients that is little understood or treated. Cytotoxic drugs …

Acute gout attacks produce severe joint pain and inflammation associated with monosodium
urate (MSU) crystals leading to oxidative stress production. The transient potential receptor …

ABSTRACT Acetaminophen [N‐acetyl‐p‐aminophenol (APAP)] is the most common
antipyretic/analgesic medicine worldwide. If APAP is overdosed, its metabolite, N‐acetyl‐p …

Although feverfew has been used for centuries to treat pain and headaches and is
recommended for migraine treatment, the mechanism for its protective action remains …

The transient potential vanilloid 1 receptor (TRPV1) is a calcium-permeable channel
responsible for the transduction and modulation of acute and chronic pain signaling. As …