BACKGROUND Osteoarthritis (OA) is the most common joint disease encountered
throughout Europe. A task force for the EULAR Standing Committee for Clinical Trials met in …

Objective. To investigate the appearance of hypertrophic chondrocytes in osteoarthritic (OA)
cartilage, using type X collagen as a specific marker. Methods. The biosynthesis of type X …

Objective Matrilin-3 is a member of the recently described matrilin family of extracellular
matrix proteins containing von Willebrand factor A-like domains. The matrilin-3 subunit can …

Normal and osteoarthritic human articular cartilage was investigated by in situ hybridization
for expression patterns of the fibrillar collagens type I, II, and III to evaluate phenotypic …

Osteocalcin (OC), which is a marker of the mature osteoblasts, can also be found in
posthypertrophic chondrocytes of the epiphyseal growth plate, but not in chondrocytes of the …

OBJECTIVE To determine the levels of vascular endothelial growth factor (VEGF) mRNA
and protein expression in normal and osteoarthritic (OA) human articular cartilage, and …

A new instrument for simultaneous microbeam small-and wide-angle X-ray scattering and X-
ray fluorescence (SAXS/WAXS/XRF) is presented. The instrument is installed at the …

Osteopontin, a sulfated phosphoprotein with cell binding and matrix binding properties, is
expressed in a variety of tissues. In the embryonic growth plate, osteopontin expression was …

In situ hybridization and immunohistochemical techniques were applied to investigate gene
expression and extracellular deposition of collagen type II in normal, osteoarthritic and …

OBJECTIVE Thrombospondin-1 (TSP-1), a trimeric glycoprotein, is involved in cell-matrix
interactions of various tissues, particularly in cartilage. Biochemical analyses show …