Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
MC Castaño Betancourt, F Cailotto… - Proceedings of the …, 2012 - National Acad Sciences
Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large
genetic component that is, however, still ill-defined. To date, genome-wide association …
genetic component that is, however, still ill-defined. To date, genome-wide association …
[HTML][HTML] DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
S Monteagudo, FMF Cornelis, C Aznar-Lopez… - Nature …, 2017 - nature.com
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment,
as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme …
as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme …
[HTML][HTML] Osteomodulin downregulation is associated with osteoarthritis development
J Zappia, Q Tong, R Van der Cruyssen, FMF Cornelis… - Bone Research, 2023 - nature.com
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of
osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix …
osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix …
Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis
R Assi, C Cherifi, FMF Cornelis, Q Zhou… - Annals of the …, 2023 - ard.bmj.com
Objectives In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective
epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by …
epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by …
[HTML][HTML] Functional effects of susceptibility genes in osteoarthritis
Osteoarthritis is the most common chronic musculoskeletal disorder. Although osteoarthritis
is a multifactorial disease, it is known to have a significant genetic contribution. Identified …
is a multifactorial disease, it is known to have a significant genetic contribution. Identified …
ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone
FMF Cornelis, S Monteagudo, LAKA Guns… - Science translational …, 2018 - science.org
Osteoarthritis is the most common joint disorder with increasing global prevalence due to
aging of the population. Current therapy is limited to symptom relief, yet there is no cure. Its …
aging of the population. Current therapy is limited to symptom relief, yet there is no cure. Its …
[HTML][HTML] Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis
A De Roover, AE Núñez, FMF Cornelis, C Cherifi… - JCI insight, 2021 - ncbi.nlm.nih.gov
Osteoarthritis is the most prevalent joint disease worldwide, and it is a leading source of pain
and disability. To date, this disease lacks curative treatment, as underlying molecular …
and disability. To date, this disease lacks curative treatment, as underlying molecular …
The effect of forced exercise on knee joints in Dio2−/− mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon …
Objective To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target
in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint …
in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint …
The sacroiliac joint: An original and highly sensitive tool to highlight altered bone phenotype in murine models of skeletal disorders
S Hilliquin, V Zhukouskaya, O Fogel, C Cherifi… - Bone, 2024 - Elsevier
Bone disorders may affect the skeleton in different ways, some bones being very impaired
and others less severely. In translational studies using murine models of human skeletal …
and others less severely. In translational studies using murine models of human skeletal …
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
E Houtman, M Tuerlings, HED Suchiman… - …, 2023 - academic.oup.com
Objectives To investigate whether the deiodinase inhibitor iopanoic acid (IOP) has
chondroprotective properties, a mechanical stress induced model of human aged explants …
chondroprotective properties, a mechanical stress induced model of human aged explants …