Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Objective To develop concise, up-to-date, patient-focused, evidence-based, expert
consensus guidelines for the management of knee osteoarthritis (OA), intended to inform …

The culture of chondrocytes is one of the most powerful tools for exploring the intracellular
and molecular features of chondrocyte differentiation and activation. However, chondrocytes …

OBJECTIVE: Although most studies have focused on the cholesterol-lowering activity of
stigmasterol, other bioactivities have been ascribed to this plant sterol compound, one of …

OBJECTIVE To evaluate if type 2 diabetes is an independent risk predictor for severe
osteoarthritis (OA). RESEARCH DESIGN AND METHODS Population-based cohort study …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Within the mature articular cartilage matrix, which has no blood or nerve supply,
chondrocytes show little metabolic activity with low turnover of matrix components. Under …

Obesity, together with aging and injury, is among the main risk factors for osteoarthritis.
Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the …