Ankylosing spondylitis (AS) is a complex disease involving multiple risk factors, both genetic
and environmental. AS patients are predominantly young men, and the disease is …

Mice with the recessive motheaten (me) or the allelic viable motheaten (me v) mutations
express a severe autoimmune and immunodeficiency syndrome. We have shown that the …

Our laboratory is interested in identifying genes relevant to diseases. Our approach is to use
spontaneous mouse mutants with immunological defects and decipher the molecular basis …

Kv1. 3 channels regulate proliferation of normal lymphocytes, but the role of voltage-gated
potassium channels in transformed hematopoietic cells is not known. We examined …

Introduction The relative resistance of non-chondrodystrophic (NCD) canines to
degenerative disc disease (DDD) may be due to a combination of anabolic and anti …

Calcium pyrophosphate deposition (CPPD) disease (common in older adults) can be
asymptomatic, associated with osteoarthritis, or can present as acute/chronic inflammatory …

Objectives To assess whether there is excess transmission of alleles from the ERAP1
ERAP2 locus in families with ankylosing spondylitis (AS). Methods 199 multiplex families …

The ank (progressive ankylosis) mutant mouse, which has a nonsense mutation in exon 12
of the inorganic pyrophosphate regulator gene (ank), exhibits aberrant joint ankylosis similar …

Background Unravelling the basis of joint inflammation and ankylosis represents a major
challenge in ankylosing spondylitis (AS) research. As noggin (NOG) and sclerostin (SOST) …

Human and mouse IgM can be polymerized as a hexamer in addition to a pentamer. Our
previous work with mouse IgM measured activation of guinea pig complement by highly …