Ankylosing spondylitis: an autoimmune or autoinflammatory disease?
Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
[HTML][HTML] Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications
Cell to cell communication is essential for the coordination and proper organization of
different cell types in multicellular systems. Cells exchange information through a multitude …
different cell types in multicellular systems. Cells exchange information through a multitude …
[HTML][HTML] Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
[HTML][HTML] Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
Gut microbial dysbiosis is associated with the development of autoimmune disease, but the
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …
Brief report: intestinal dysbiosis in ankylosing spondylitis
ME Costello, F Ciccia, D Willner… - Arthritis & …, 2015 - Wiley Online Library
Objective Ankylosing spondylitis (AS) is a common, highly heritable immune‐mediated
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but …
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but …
The gut–joint axis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …
Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing …
Background The aim of the study was to better characterise the immunological origin and
the behaviour of interleukin (IL)-23-responsive innate lymphoid cells (ILCs) in the gut …
the behaviour of interleukin (IL)-23-responsive innate lymphoid cells (ILCs) in the gut …
Overexpression of interleukin‐23, but not interleukin‐17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis
F Ciccia, M Bombardieri, A Principato… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Subclinical gut inflammation is common in spondylarthritis, but the immunologic
abnormalities underlying this process are undefined. Perturbation of the interleukin‐23 (IL …
abnormalities underlying this process are undefined. Perturbation of the interleukin‐23 (IL …
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis
Background Dysbiosis has been recently demonstrated in patients with ankylosing
spondylitis (AS) but its implications in the modulation of intestinal immune responses have …
spondylitis (AS) but its implications in the modulation of intestinal immune responses have …
[HTML][HTML] Efficacy and safety of rituximab treatment in early primary Sjögren's syndrome: a prospective, multi-center, follow-up study
…, S Alvaro, A Alunno, A Manzo, F Ciccia… - Arthritis research & …, 2013 - Springer
Abstract Introduction Primary Sjögren's syndrome (pSS) is an autoimmune disorder affecting
exocrine glands; however, a subgroup of pSS patients experience systemic extra-glandular …
exocrine glands; however, a subgroup of pSS patients experience systemic extra-glandular …