[HTML][HTML] Intracellular Calcium Signals Regulating Cytosolic Phospholipase A2 Translocation to Internal Membranes* 210

JH Evans, DM Spencer, A Zweifach… - Journal of Biological …, 2001 - ASBMB
Increased intracellular Ca 2+ concentrations ([Ca 2+] i) promote cytosolic phospholipase A 2
(cPLA 2) translocation to intracellular membranes. The specific membranes to which cPLA 2 …

[HTML][HTML] Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium: novel role of mitogen …

MA Gijón, DM Spencer, AR Siddiqi… - Journal of biological …, 2000 - ASBMB
The 85-kDa cytosolic phospholipase A 2 (cPLA 2) mediates agonist-induced arachidonic
acid release and eicosanoid production. Calcium and phosphorylation on Ser-505 by …

Role of Phosphorylation Sites and the C2 Domain in Regulation of Cytosolic Phospholipase A2

MA Gijón, DM Spencer, AL Kaiser… - The Journal of cell …, 1999 - rupress.org
Cytosolic phospholipase A2 (cPLA2) mediates agonist-induced arachidonic acid release,
the first step in eicosanoid production. cPLA2 is regulated by phosphorylation and by …

Assay variation in the detection of antinuclear antibodies in the sera of patients with established SLE

DS Pisetsky, DM Spencer, PE Lipsky… - Annals of the rheumatic …, 2018 - ard.bmj.com
Objective The expression of antinuclear antibodies (ANA) is considered almost constant in
systemic lupus erythematosus (SLE), although recent experience has suggested that many …

[HTML][HTML] The role of calcium and phosphorylation of cytosolic phospholipase A2 in regulating arachidonic acid release in macrophages

ZH Qiu, MA Gijón, MS de Carvalho, DM Spencer… - Journal of Biological …, 1998 - ASBMB
Arachidonic acid release is induced in macrophages with diverse agonists including calcium
ionophores, phorbol myristate acetate (PMA), okadaic acid, and the phagocytic particle …

[HTML][HTML] Enzymatic properties of human cytosolic phospholipase A2γ

A Stewart, M Ghosh, DM Spencer, CC Leslie - Journal of Biological …, 2002 - ASBMB
The enzymatic properties of cytosolic phospholipase A 2 γ (cPLA 2 γ), an isoform of 85-kDa
group IV cPLA 2 α (cPLA 2 α) were studied in vitro and when the enzyme was expressed in …

The expression of antibodies to Z-DNA in the blood of patients with systemic lupus erythematosus: Relationship to autoantibodies to B-DNA

DM Spencer, E Svenungsson, I Gunnarsson… - Clinical …, 2023 - Elsevier
To explore the antibody response to Z-DNA, a DNA conformation with a zig-zag structure,
blood of patients with systemic lupus erythematosus (SLE) and otherwise healthy individuals …

[HTML][HTML] The interaction of anti-DNA antibodies with DNA: evidence for unconventional binding mechanisms

DS Pisetsky, A Garza Reyna, ME Belina… - International Journal of …, 2022 - mdpi.com
Antibodies to DNA (anti-DNA) are the serological hallmark of systemic lupus erythematosus,
a prototypic autoimmune disease. These antibodies bind to conserved sites on single …

DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona

DM Griffith, DT Jayaram, DM Spencer, DS Pisetsky… - …, 2020 - pubs.aip.org
There has been much recent interest in the protein “corona,” the nonspecific adsorption of
proteins on the surface of nanoparticles used in biological applications. This research …

The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis

DM Spencer, J Gauley, DS Pisetsky - Innate immunity, 2014 - journals.sagepub.com
Microparticles (MPs) are small, membrane-bound vesicles that arise from dead and dying
cells, and display pro-inflammatory and pro-thrombotic activity. As shown previously, the …