Background The value of intensive combination therapy in early rheumatoid arthritis is
unproven. In a multicentre, double-blind, randomised trial (COBRA), we compared the …

Out of 104 patients with microcytosis (MCV< 80 fl), 69% had an iron deficiency, 21% a
chronic disease and 10%, hemoglobinopathy or thalassemia trait. The absence of bone …

Background: In patients with early rheumatoid arthritis, initial combination therapies provide
earlier clinical improvement and less progression of joint damage after 1 year compared …

Patients with rheumatoid arthritis (RA) carry an excess risk for cardiovascular disease, which
is comparable to the risk in patients with type 2 diabetes mellitus. The mechanisms involved …

Objective To determine associations of methotrexate (MTX) efficacy and toxicity with single‐
nucleotide polymorphisms (SNPs) in genes coding for folate pathway enzymes in patients …

Serum rheumatoid factors (RF) were measured yearly in 135 women with rheumatoid
arthritis by the Waaler-Rose and latex fixation tests and IgM, IgA, and IgG RF were …

Objective To determine the most effective induction disease-modifying antirheumatic drug
(DMARD) strategy in early rheumatoid arthritis (RA), second to compare one single dose of …

Objectives To compare 1-year clinical efficacy of (1) initial triple disease-modifying
antirheumatic drug therapy (iTDT) with initial methotrexate (MTX) monotherapy (iMM) and …

The association between HLA–DR antigens and rheumatoid arthritis (RA) was investigated
in a wellcharacterized cohort of RA patients who were followed from the beginning of the …

Objectives: To compare the clinical and radiological efficacy of initial vs delayed treatment
with methotrexate (MTX) and infliximab (IFX) in patients with recent onset rheumatoid …