Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial
GA Lewis, S Dodd, D Clayton, E Bedson, H Eccleson… - Nature Medicine, 2021 - nature.com
In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial
fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent …
fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent …
[HTML][HTML] Pirfenidone in heart failure with preserved ejection fraction—rationale and design of the PIROUETTE trial
GA Lewis, EB Schelbert, JH Naish, E Bedson… - … drugs and therapy, 2019 - Springer
Abstract Background The PIROUETTE (PIRfenidOne in patients with heart failUre and
preserved lEfT venTricular Ejection fraction) trial is designed to evaluate the efficacy and …
preserved lEfT venTricular Ejection fraction) trial is designed to evaluate the efficacy and …
Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT
Background People with cystic fibrosis are susceptible to pulmonary infection with
Pseudomonas aeruginosa. This may become chronic and lead to increased mortality and …
Pseudomonas aeruginosa. This may become chronic and lead to increased mortality and …
Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy
J Farrant, S Dodd, C Vaughan, A Reid, M Schmitt… - Heart, 2023 - heart.bmj.com
Aims Hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy
(LVH), myocardial fibrosis, enhanced oxidative stress and energy depletion …
(LVH), myocardial fibrosis, enhanced oxidative stress and energy depletion …
Individual variation between general practitioners in labelling of hypertension.
TD Smith, D Clayton - British Medical Journal, 1990 - bmj.com
Variation in labelling of hypertension by individual general practitioners was studied during
a continuous opportunistic screening programme for hypertension in a single general …
a continuous opportunistic screening programme for hypertension in a single general …
[HTML][HTML] Humidified and standard oxygen therapy in acute severe asthma in children (HUMOX): A pilot randomised controlled trial
PS McNamara, D Clayton, C Burchett, V Compton… - Plos one, 2022 - journals.plos.org
Background Oxygen (O2) is a mainstay of treatment in acute severe asthma but how it is
administered varies widely. The objectives were to examine whether a trial comparing …
administered varies widely. The objectives were to examine whether a trial comparing …
[HTML][HTML] Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study.
AP Jones, D Clayton, G Nkhoma… - Health Technology …, 2020 - ncbi.nlm.nih.gov
BACKGROUND In the UK, juvenile idiopathic arthritis is the most common inflammatory
disorder in childhood, affecting 10: 100,000 children and young people aged< 16 years …
disorder in childhood, affecting 10: 100,000 children and young people aged< 16 years …
Protocol for a definitive randomised controlled trial and economic evaluation of a community-based rehabilitation programme following hip fracture: fracture in the …
N Williams, S Dodd, B Hardwick, D Clayton… - BMJ open, 2020 - bmjopen.bmj.com
Introduction Proximal femoral (hip) fracture is common, serious and costly. Rehabilitation
may improve functional recovery but evidence of effectiveness and cost-effectiveness are …
may improve functional recovery but evidence of effectiveness and cost-effectiveness are …
[HTML][HTML] Literature review on the use of corticosteroids in juvenile idiopathic arthritis
AP Jones, D Clayton, G Nkhoma… - … induction regimens in …, 2020 - ncbi.nlm.nih.gov
Aim and objectives Our aim was to undertake a literature review on the use of CSs in
children with JIA. Our objectives were to identify whether or not there is a standardised use …
children with JIA. Our objectives were to identify whether or not there is a standardised use …
Humidified and standard oxygen therapy in acute severe asthma in children: a randomised controlled pilot trial (HUMOX)
V Compton, M Peak, J Grice, J Clark, L Lee, C Burchett… - 2018 - Eur Respiratory Soc
Background: Oxygen (O 2) is a mainstay of treatment in acute severe asthma. While there
are physiological reasons why O 2 should be warmed and humidified, how O 2 is …
are physiological reasons why O 2 should be warmed and humidified, how O 2 is …