The importance of understanding the stages of COVID-19 in treatment and trials.

…, J Iglesias, M Dube, N Nanda, GK In, D Arkfeld… - AIDS …, 2021 - search.ebscohost.com
Abstract COVID-19, caused by SARS-CoV-2, continues to be a major health problem since
its first description in Wuhan, China, in December 2019. Multiple drugs have been tried to …

Etanercept therapy in rheumatoid arthritis: a randomized, controlled trial

LW Moreland, MH Schiff, SW Baumgartner… - Annals of internal …, 1999 - acpjournals.org
Background: In a phase II study, etanercept (recombinant human tumor necrosis factor
receptor [p75]: Fc fusion protein) safely produced rapid, dose-dependent improvement in …

The time to offer treatments for COVID-19

…, M Dubé, N Nanda, G In, D Arkfeld… - Expert opinion on …, 2021 - Taylor & Francis
Background: COVID-19 has several overlapping phases. Treatments to date have focused
on the late stage of disease in hospital. Yet, the pandemic is by propagated by the viral …

Chronic pain in patients with rheumatoid arthritis

K Mathias, A Amarnani, N Pal, J Karri, D Arkfeld… - Current Pain and …, 2021 - Springer
Abstract Purpose of Review Chronic pain is highly prevalent in patients with rheumatoid
arthritis (RA) and can cause various physical and psychological impairments. Unfortunately …

Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis

SM Tan, D Xu, V Roschke, JW Perry… - … : Official Journal of …, 2003 - Wiley Online Library
Objective To determine whether synovial fluid (SF) levels and cell‐surface expression of B
lymphocyte stimulator (BLyS) protein and SF levels of APRIL are elevated in patients with …

Tear cathepsin S as a candidate biomarker for Sjögren's syndrome

SF Hamm‐Alvarez, SR Janga, MC Edman… - Arthritis & …, 2014 - Wiley Online Library
Objective The diagnosis of Sjögren's syndrome (SS) in routine practice is largely a clinical
one and requires a high index of suspicion by the treating physician. This great dependence …

Rituximab treatment for resistant antiphospholipid syndrome.

E Rubenstein, DG Arkfeld, S Metyas… - The Journal of …, 2006 - jrheum.org
Antiphospholipid syndrome (APS) and catastrophic antiphospholipid syndrome (CAPS) can
be challenging to treat. As they are rare, clinicians are not often exposed to these complex …

Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages

EC Tsark, W Wang, YC Teng, D Arkfeld… - The Journal of …, 2002 - journals.aai.org
Rheumatoid arthritis is characterized by synovial joint infiltration of activated CD4+ T cells
and MHC class II+ APC, and is linked to specific HLA-DR alleles. Candidate autoantigens in …

[HTML][HTML] Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients

MC Edman, SR Janga, Z Meng, M Bechtold, AF Chen… - Scientific reports, 2018 - nature.com
Cathepsin S (CTSS) activity is elevated in Sjögren's Syndrome (SS) patient tears. Here we
tested whether protease inhibition and cystatin C (Cys C) levels are reduced in SS tears …

Identification of neisseria gonorrhoeae in synovial fluid using the polymerase chain reaction

MR Liebling, DG Arkfeld, GA Michelini… - … : Official Journal of …, 1994 - Wiley Online Library
Objective. To analyze synovial fluid (SF) for the presence of Neisseria gonorrhoeae DNA
using the polymerase chain reaction (PCR). Methods. We used a modified, nested PCR to …