Objective To develop new classification criteria for systemic lupus erythematosus (SLE)
jointly supported by the European League Against Rheumatism (EULAR) and the American …

Vitamin D has received increased attention recently for its pleiotropic actions on many
chronic diseases. The importance of vitamin D on the regulation of cells of the immune …

Evidence from animal models and prospective studies of RA, multiple sclerosis, and type-1
diabetes suggest an important role for vitamin D as a modifiable environmental factor in …

Abstract Objective The Systemic Lupus International Collaborating Clinics (SLICC) group
revised and validated the American College of Rheumatology (ACR) systemic lupus …

In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct
antimicrobial activity against intracellular bacteria, which in murine, but not human …

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

Background and aims We studied damage accrual and factors determining development
and progression of damage in an international cohort of systemic lupus erythematosus …

Objective. To determine nephritis outcomes in a prospective multi-ethnic/racial SLE
inception cohort. Methods. Patients in the Systemic Lupus International Collaborating Clinics …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

Genome-wide association studies (GWAS) have identified 36 loci associated with body
mass index (BMI), predominantly in populations of European ancestry. We conducted a …