Treatment recommendations for psoriatic arthritis

…, WH Boehncke, K De Vlam, D Fiorentino… - Annals of the …, 2009 - ard.bmj.com
Objective: To develop comprehensive recommendations for the treatment of the various
clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a …

The mechanism of action of cyclosporin A and FK506

…, J Northrop, I Graef, D Fiorentino… - Clinical immunology and …, 1996 - Elsevier
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune
response by inhibiting evolutionary conserved signal transduction pathways. CsA, FK506 …

Cutaneous vasculitis

DF Fiorentino - journal of the american academy of dermatology, 2003 - Elsevier
Vasculitis can range in severity from a self-limited single-organ disorder to a life-threatening
disease with the prospect of multiple-organ failure. This condition presents many challenges …

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

DF Fiorentino, MW Bond, TR Mosmann - The Journal of experimental …, 1989 - rupress.org
A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A
or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones. CSIF …

IL-10 inhibits cytokine production by activated macrophages.

DF Fiorentino, A Zlotnik, TR Mosmann… - … (Baltimore, Md.: 1950 …, 1991 - journals.aai.org
IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by
Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both …

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

DF Fiorentino, A Zlotnik, P Vieira… - … (Baltimore, Md.: 1950 …, 1991 - journals.aai.org
Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell
clones when they are activated under conditions requiring the presence of APC. By …

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI

KW Moore, P Vieira, DF Fiorentino, ML Trounstine… - Science, 1990 - science.org
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF;
interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and …

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

P Vieira, R de Waal-Malefyt, MN Dang… - Proceedings of the …, 1991 - National Acad Sciences
We have demonstrated the existence of human cytokine synthesis inhibitory factor
(CSIF)[interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated …

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

DH Hsu, RW Malefyt, DF Fiorentino, MN Dang, P Vieira… - Science, 1990 - science.org
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell
clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive …

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

CJ Kuo, J Chung, DF Fiorentino, WM Flanagan… - Nature, 1992 - nature.com
THE macrolide rapamycin induces cell cycle Gl arrest in yeast and in mammalian cells1–3,
which suggests that an evolutionarily conserved, rapamycin-sensitive pathway may regulate …