Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

L Wieske, KPJ van Dam, M Steenhuis… - The Lancet …, 2022 - thelancet.com
Background Disease-specific studies have reported impaired humoral responses after
SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders treated …

Breakthrough SARS-CoV-2 infections with the delta (B. 1.617. 2) variant in vaccinated patients with immune-mediated inflammatory diseases using …

L Boekel, EW Stalman, L Wieske… - The Lancet …, 2022 - thelancet.com
Background Concerns have been raised regarding the risks of SARS-CoV-2 breakthrough
infections in vaccinated patients with immune-mediated inflammatory diseases treated with …

[HTML][HTML] Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

L Wieske, LYL Kummer, KPJ van Dam, EW Stalman… - BMC medicine, 2022 - Springer
Background Studies have suggested incremental short-term adverse events (AE) after
repeated vaccination. In this report, we assessed occurrence and risk factors for short-term …

Breakthrough infections with the SARS-CoV-2 omicron (B. 1.1. 529) variant in patients with immune-mediated inflammatory diseases

EW Stalman, L Wieske, KPJ van Dam… - Annals of the …, 2022 - ard.bmj.com
Objectives To compare the cumulative incidence and disease severity of reported SARS-
CoV-2 omicron breakthrough infections between patients with immune-mediated …

Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations

KPJ van Dam, L Wieske, EW Stalman… - Journal of …, 2023 - Elsevier
For patients with immune-mediated inflammatory diseases (IMIDs), concerns exist about
increased disease activity after vaccination. We aimed to assess changes in disease activity …

[HTML][HTML] mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses

J van den Dijssel, MC Duurland, VAL Konijn… - Journal of …, 2024 - Elsevier
Abstract SARS-CoV-2-specific CD8+ T cells recognize conserved viral peptides and in the
absence of cross-reactive antibodies form an important line of protection against emerging …

[HTML][HTML] Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

KPJ Van Dam, AG Volkers, L Wieske… - BMC Infectious …, 2023 - Springer
Background Patients with immune-mediated inflammatory diseases (IMIDs) on
immunosuppressants (ISPs) may have impaired long-term humoral immune responses and …

Suppressed IgG4 class switching in dupilumab‐and TNF inhibitor‐treated patients after mRNA vaccination

AM Valk, JBD Keijser, KPJ van Dam, EW Stalman… - Allergy, 2024 - Wiley Online Library
Background The noninflammatory immunoglobulin G4 (IgG4) is linked to tolerance and is
unique to humans. Although poorly understood, prolonged antigenic stimulation and IL‐4 …

Suppressed IgG4 class switching in dupilumab-and TNF inhibitor-treated patients after repeated SARS-CoV-2 mRNA vaccination

AM Valk, JBD Keijser, K Dam, E Stalman, L Wieske… - medRxiv, 2023 - medrxiv.org
Background Repeated mRNA vaccination against SARS-CoV-2 has been shown to induce
class switching to IgG4, a non-inflammatory human antibody subclass linked to tolerance …

Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases

L Wieske, EW Stalman, PJK van Dam… - Annals of the …, 2023 - ard.bmj.com
Patients with immune-mediated inflammatory diseases (IMIDs) may have impaired initial
humoral responses after SARS-CoV-2 vaccination depending on the type of …