Several studies have highlighted the interplay between metabolism, immunity and
inflammation. Both tissue resident and infiltrating immune cells play a major role in the …

Objectives To unravel the hierarchy of cellular/molecular pathways in the disease tissue of
early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship …

Immune-mediated inflammatory diseases (IMIDs) are responsible for substantial global
disease burden and associated health-care costs. Traditional models of research and …

Objectives Synovial fibroblasts actively regulate the inflammatory infiltrate by communicating
with neighbouring endothelial cells (EC). Surprisingly, little is known about how the …

Background The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an
intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation …

Background: Tissue fibrosis and microvascular rarefaction are hallmarks of progressive
renal disease. CD248 is a transmembrane glycoprotein expressed by key effector cells …

Objectives Controlled immune responses rely on integrated crosstalk between cells and
their microenvironment. We investigated whether targeting proinflammatory signals from the …

SIR, Adhesive capsulitis (frozen shoulder) is a remarkable example of a severe, yet self-
limiting, inflammatory and fibrotic condition affecting the shoulder joint capsule. Patients …

Objectives The severity of skin involvement in diffuse cutaneous systemic sclerosis (dcSSc)
depends on stage of disease and differs between anti-RNA-polymerase III (ARA) and anti …

In the version of the article initially published, there were errors in Fig. 1b. The boxes for IL-
23 under “Axial spondyloarthritis” and for CTLA-4 under “Psoriasis” were mistakenly shown …