MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a
changing environment by modulating the cell transcriptome. miR-155 is a multifunctional …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as
mediators of disease pathology via coordinated regulation of molecular effector pathways …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

Rationale: Active smoking in asthma is associated with worsening of symptoms, accelerated
decline in lung function, and impaired response to corticosteroids. Objectives: To examine …

The hypothesis that homoeopathic potencies are placebos was tested in a randomised,
double-blind, placebo-controlled trial. The study model chosen compared the effects of a …

Study objectives Cigarette smoking is common in asthmatic patients, and we investigated
the impact of cigarette smoking on airway inflammation in asthma. Design Single-center …

Objective: To estimate trends between 1972–6 and 1996 in the prevalences of asthma and
hay fever in adults. Design: Two epidemiological surveys 20 years apart. Identical questions …

Background The initiation and regulation of pulmonary fibrosis are not well understood. IL-
33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients …

Objective: To test the hypothesis that homoeopathy is a placebo by examining its effect in
patients with allergic rhinitis and so contest the evidence from three previous trials in this …