Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …

Association studies of over 1 million SNPs capturing most of the human genome common
variation became possible thanks to the information provided by the HapMap International …

Purpose Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin
resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in …

Objectives Altered signalling in B cells is a predominant feature of systemic lupus
erythematosus (SLE). The genes BANK1 and BLK were recently described as associated …

CRISPR/Cas9 has revolutionized the genome-editing field. So far, successful application in
human adipose tissue has not been convincingly shown. We present a method for gene …

The B cell adaptor protein with ankyrin repeats (BANK1) and the B lymphoid tyrosine kinase
(BLK) have been genetically associated with autoimmunity. The proteins of these genes …

Serine proteases play a central role in defense against pathogens by regulating processes
such as blood clotting, melanization of injured surfaces, and proteolytic activation of …

Neurochondrin (NCDN) is a cytoplasmatic neural protein of importance for neural growth,
glutamate receptor (mGluR) signaling, and synaptic plasticity. Conditional loss of Ncdn in …

Objectives To perform fine mapping of the autoimmunity susceptibility gene BLK and identify
functional variants involved in systemic lupus erythematosus (SLE). Methods Genotyping of …

Fat cadherins constitute a subclass of the large cadherin family characterized by the
presence of 34 cadherin motifs. To date, three mammalian Fat cadherins have been …